Introduction: Despite 30 years of history, assisted reproduction technologies(ART) still present many challenges in order to identify factors and predictors of success.It is well known that oocyte quality is the main factor determining chance of pregnancy and that poor qualityis an obstacle for successful in vitro fertilization results.It has become increasingly clear that the follicular micro environment of a human oocyte is a crucial factor for its developmental competence.
Through the years, many studies have been proposed tofind strategies, drugs, or compounds such as antioxidant drugs and supplementation with vitamins or hormones ableto improve oocyte quality and embryo quality.
Recently, studies on inositol supplementation duringin vitro fertilization program (IVF) have gained particularimportance due to the effect of this molecule on reducinginsulin resistance improving ovarian function, oocyte quality,and embryo and pregnancy rates and reducing gonadotropinamount during stimulation. Inositol and its isoform,especially myoinositol, find their application as prestimulationtherapy in polycystic ovary syndrome (PCOS) patientsundergoing IVF cycle and, recently, also in all kinds of infertile patients such as poor responders.
Studies demonstrate that the use of inositol in male patients affected by oligoasthenoteratozoospermia can improve sperm cell parameters and consequently the impact of fertilization rate and embryo quality leading to high percentage ofpregnancy.